Speaker
M. Ermelinda Eusebio
(Department of Chemistry, University of Coimbra)
Description
`The investigation of solid forms of organic compounds and its structural characterization is an area of active research. It is particularly relevant in what concerns active pharmaceutical ingredients [1, 2], but also in all other domains where differences in the solid-state form may impact the material properties [3, 4]. Polymorphs of the pure compound, solvates, salts, co-crystals and their polymorphs, are different types of solid forms of organic compounds that may be considered, which may have different physicochemical properties. Nevertheless, the design and reproducible preparation of particular solid forms is far to be predictable and each compound represents a new challenge. From the combined efforts of the scientific community, contributions to understand and, if possible, to control the solid state chemistry of a target compound may be expected.`
`This communication will focus on two aspects of the research on the solid state of organic compounds that is been carried out in our laboratory. Results will be presented on the investigation of co-crystals, including some that exhibit liquid crystalline mesophases. The second topic to be addressed, concerns an investigation on the polymorphism of cyclohexanediol derivatives and on their different ability to give rise to plastic crystal mesophases.`
References
[1] C.R. Gardner, C.T. Walsh, Ö. Almarsson, `$\textit{Nat. Rev. Drug Discov.}$`, `$\textbf{3}$`, 926 (2004).
[2] N.K. Duggirala, M.L. Perry, Ö.Almarsson, M.J. Zaworotko, `$\textit{Chem. Comm.}$`, `$\textbf{52}$`, 640 (2016).
[3] K.B. Landenberger, O. Bolton, A.J. Matzger, `$\textit{J. Am. Chem. Soc.}$`, `$\textbf{137}$`, 5074 (2015).
[4] E.F. Paulus, F.J.J. Leusen, M.U. Schmidt, `$\textit{CrystEngComm}$`, `$\textbf{9}$`, 131 (2007).
Primary author
M. Ermelinda Eusebio
(Department of Chemistry, University of Coimbra)
Co-authors
João Canotilho
(Faculty of Pharmacy, University of Coimbra)
Prof.
Manuela Silva
(Department of Chemistry, University of Coimbra)
Mário Rosado
(Department of Chemistry, University of Coimbra)
Ricardo Castro
(Faculty of Pharmacy, University of Coimbra)
Teresa Maria
(Department of Chemistry, University of Coimbra)
