A scheme of NLO computations of generic observables in high-energy hadron-hadron collisions within the framework of high-energy factorization (HEF) with one off-shell initial-state parton is derived. By taking a high-energy limit of the NLO computation in collinear factorization (CF), the NLO terms belonging to the projectile and target are identified and the ambiguity of projectile-target separation is related with the Collins-Soper scale mu_Y. The NLO unintegrated PDF(UPDF) is constructed in terms of the usual PDFs, and its mu_Y-evolution reproduces the Collins-Soper-Sterman equation in the TMD limit (k_T<<mu_Y). The resummation of high-energy logarithms is taken care of by the BFKL-Collins-Ellis evolution of the Green's function in the UPDF.