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SUMMARY:Hidden mesoscale order in Posaconazole: A comparative study with I
 traconazole
DTSTART:20261027T100000Z
DTEND:20261027T110000Z
DTSTAMP:20261104T151600Z
UID:indico-event-1712@indico.ifj.edu.pl
DESCRIPTION:Speakers: Gopika Mohandas (Faculty of Science and Technology\,
  University of Silesia\, Katowice\, Poland)\n\nLiquid-crystalline-like ord
 ering in amorphous pharmaceuticals can govern their molecular mobility\, p
 hysical stability\, and crystallization - properties that ultimately deter
 mine the performance of amorphous drug materials. Here\, the azole antifun
 gal drugs posaconazole (POS) and itraconazole (ITR) are used as model syst
 ems to investigate the interplay between mesoscale organization and molecu
 lar dynamics. Using ITR\, which forms well-defined liquid-crystalline phas
 es\, as a reference\, we reveal an analogous but hidden orientational orde
 r in amorphous posaconazole\, despite the absence of a stable liquid-cryst
 alline phase. Broadband dielectric and shear mechanical spectroscopy show 
 that this order is accompanied by an additional slow process beyond the st
 ructural relaxation. Complementary atomic force microscopy (AFM) reveals s
 tripe-like modulations of the local stiffness at the surface (≈ 2.5 µm 
 for ITR\, ≈ 1 µm for POS)\, attributed to frozen-in smectic layering in
  ITR and to surface-enhanced orientational order in POS. We further demons
 trate that high-pressure helium treatment disrupts this ordering in both c
 ompounds\, plasticizes the glass\, erases the surface stripe patterns and 
 measurably increases the tendency towards recrystallization. These results
  introduce noble-gas compression as an additive-free route to modify the m
 esoscale order of such rod-like molecular systems.\n\nhttps://indico.ifj.e
 du.pl/event/1712/
LOCATION:online via Zoom platform (IFJ PAN)
URL:https://indico.ifj.edu.pl/event/1712/
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