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SUMMARY:Topological aspects and computational approaches for intrinsically
  disordered protein systems
DTSTART:20261020T090000Z
DTEND:20261020T100000Z
DTSTAMP:20261104T143300Z
UID:indico-event-1706@indico.ifj.edu.pl
DESCRIPTION:Speakers: Mateusz Chwastyk (Institute of Physics\, Polish Acad
 emy of Sciences\, Warsaw\, Poland)\n\nIntrinsically disordered proteins (I
 DPs) pose significant challenges for computational modelling due to their 
 conformational flexibility and the complexity of their interaction network
 s. Their description requires methods capable of capturing structural orga
 nization across different spatial scales\, from local amino-acid interacti
 ons to the collective behaviour of entire protein chains. In this talk\, I
  will focus on topological aspects of IDP systems and numerical methods fo
 r their characterization\, with particular emphasis on the SPACEBALL algor
 ithm and its applications. I will discuss how mathematical and computation
 al approaches can be used to investigate the structural organization of di
 sordered protein systems and characterize interactions at the residue leve
 l. Particular attention will be given to the relationship between local in
 teraction patterns and global structural properties\, as well as to the ro
 le of these features in protein aggregation and amyloid formation. These p
 henomena are relevant to understanding neurodegenerative diseases and the 
 formation of membranelessorganelles\, in which IDPs often play a central r
 ole. The talk will highlight how topological analysis and numerical modell
 ing can contribute to a more systematic understanding of these complex sys
 tems\, with examples illustrating the application of the SPACEBALL algorit
 hm to their computational investigation.\n\nhttps://indico.ifj.edu.pl/even
 t/1706/
LOCATION:4003\, "skyscraper" ground floor (IFJ PAN\, hybrid)
URL:https://indico.ifj.edu.pl/event/1706/
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